Version 5.4
| Homo sapiens Gene: FOLR3 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-63222.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | FOLR3 | ||||||||||||||||||
| Gene Name | folate receptor 3 (gamma) | ||||||||||||||||||
| Synonyms | FR-G; FR-gamma; gamma-hFR | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000110203 | ||||||||||||||||||
| Encoded Proteins |
folate receptor 3 (gamma)
folate receptor 3 (gamma)
folate receptor 3 (gamma)
folate receptor 3 (gamma)
folate receptor 3 (gamma)
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a member of the folate receptor (FOLR) family, members of which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This gene includes two polymorphic variants; the shorter one has two base deletion in the CDS, resulting in a truncated polypeptide, compared to the longer one. Both protein products are constitutively secreted in hematopoietic tissues and are potential serum marker for certain hematopoietic malignancies. The longer protein has a 71% and 79% sequence homology with the FOLR1 and FOLR2 proteins, respectively. [provided by RefSeq, Jul 2008] This gene encodes a member of the folate receptor (FOLR) family, members of which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This gene includes two polymorphic variants; the shorter one has two base deletion in the CDS, resulting in a truncated polypeptide, compared to the longer one. Both protein products are constitutively secreted in hematopoietic tissues and are potential serum marker for certain hematopoietic malignancies. The longer protein has a 71%% and 79%% sequence homology with the FOLR1 and FOLR2 proteins, respectively. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 11:72114869-72139892 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q13.4 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME | |||||||||||||||||||
| KEGG |
Endocytosis pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | F5H2G8 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 2352 | ||||||||||||||||||
| UniGene | Hs.352 Hs.732752 | ||||||||||||||||||
| RefSeq | NM_000804 | ||||||||||||||||||
| HUGO | HGNC:3795 | ||||||||||||||||||
| OMIM | 602469 | ||||||||||||||||||
| CCDS | CCDS73344 | ||||||||||||||||||
| HPRD | 03918 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AP000812 | ||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | 2352 | ||||||||||||||||||