InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TPH1

Summary

InnateDB Gene

IDBG-632327.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TPH1

Gene Name

Uncharacterized protein

Synonyms

SERGEF

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005343

Encoded Proteins

IDBP-683961

tryptophan hydroxylase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23243271

[Mus musculus] Tph1-deficient mice lack non-neuronal serotonin, and show impairment in neutrophil recruitment to sites of acute inflammation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129167:
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:34990951-35011243

Strand

Forward strand

Band

Transcripts

ENSBTAT00000007030

ENSBTAP00000007030

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0004510	tryptophan 5-monooxygenase activity
GO:0005506	iron ion binding
GO:0016597	amino acid binding
GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

Biological Process

GO:0008152	metabolic process
GO:0009072	aromatic amino acid family metabolic process
GO:0042427	serotonin biosynthetic process
GO:0046849	bone remodeling
GO:0055114	oxidation-reduction process
GO:0060749	mammary gland alveolus development