Version 5.4
Bos taurus Gene: HAX1
Summary
InnateDB Gene IDBG-632533.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HAX1
Gene Name HCLS1-associated protein X-1
Synonyms HAX-1
Species Bos taurus
Ensembl Gene ENSBTAG00000013025
Encoded Proteins
IDBP-684154
HCLS1-associated protein X-1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143575:
The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:16307944-16310536
Strand Reverse strand
Band
Transcripts
ENSBTAT00000017314 ENSBTAP00000017314
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Predicted by orthology
Total 43 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019966 interleukin-1 binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030833 regulation of actin filament polymerization
GO:0030854 positive regulation of granulocyte differentiation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051897 positive regulation of protein kinase B signaling
GO:0071345 cellular response to cytokine stimulus
GO:2000251 positive regulation of actin cytoskeleton reorganization
Cellular Component
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0015629 actin cytoskeleton
GO:0030027 lamellipodium
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000143575
View Gene Order
ENSMUSG00000027944
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.4007
RefSeq NM_001045953 XM_005203670 XM_005203671
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca