Version 5.4
Bos taurus Gene: RAB13
Summary
InnateDB Gene IDBG-632584.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAB13
Gene Name Ras-related protein Rab-13
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017604
Encoded Proteins
IDBP-684206
ras-related protein Rab-13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143545:
This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:16511100-16515182
Strand Forward strand
Band
Transcripts
ENSBTAT00000023407 ENSBTAP00000023407
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0006913 nucleocytoplasmic transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0010737 protein kinase A signaling
GO:0015031 protein transport
GO:0016197 endosomal transport
GO:0030866 cortical actin cytoskeleton organization
GO:0031175 neuron projection development
GO:0032456 endocytic recycling
GO:0032869 cellular response to insulin stimulus
GO:0035767 endothelial cell chemotaxis
GO:0044795 trans-Golgi network to recycling endosome transport
GO:0070830 tight junction assembly
GO:0090002 establishment of protein localization to plasma membrane
GO:0097368 establishment of Sertoli cell barrier
GO:1902463 protein localization to cell leading edge
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005923 tight junction
GO:0016020 membrane
GO:0016328 lateral plasma membrane
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0030139 endocytic vesicle
GO:0030658 transport vesicle membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0032593 insulin-responsive compartment
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000143545
View Gene Order
ENSMUSG00000027935
View Gene Order
Pathways
NETPATH
REACTOME
REACT_217718
Translocation of GLUT4 to the plasma membrane pathway
REACT_213260
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_11123
Membrane Trafficking pathway
REACT_209837
Membrane Trafficking pathway
REACT_199054
Translocation of GLUT4 to the plasma membrane pathway
KEGG
hsa04530
Tight junction pathway
mmu04530
Tight junction pathway
INOH
PID NCI
Cross-References
SwissProt Q58DS5
TrEMBL
UniProt Splice Variant
Entrez Gene 514541
UniGene Bt.4127
RefSeq NM_001024540
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC109840 BT021522
GenPept AAI09841 AAX46369
RNA Seq Atlas 514541

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca