Version 5.4
Bos taurus Gene: MECP2
Summary
InnateDB Gene IDBG-632607.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MECP2
Gene Name methyl-CpG-binding protein 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000047855
Encoded Proteins
IDBP-684235
methyl CpG binding protein 2 (Rett syndrome)
IDBP-684236
methyl CpG binding protein 2 (Rett syndrome)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169057:
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. [provided by RefSeq, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:40144448-40196621
Strand Reverse strand
Band
Transcripts
ENSBTAT00000063287 ENSBTAP00000054579
ENSBTAT00000066128 ENSBTAP00000056184
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Predicted by orthology
Total 42 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008327 methyl-CpG binding
GO:0010385 double-stranded methylated DNA binding
GO:0019904 protein domain specific binding
GO:0035197 siRNA binding
GO:0044822 poly(A) RNA binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0001662 behavioral fear response
GO:0001666 response to hypoxia
GO:0001964 startle response
GO:0001976 neurological system process involved in regulation of systemic arterial blood pressure
GO:0002087 regulation of respiratory gaseous exchange by neurological system process
GO:0006020 inositol metabolic process
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
GO:0006342 chromatin silencing
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006355 regulation of transcription, DNA-templated
GO:0006541 glutamine metabolic process
GO:0006576 cellular biogenic amine metabolic process
GO:0007268 synaptic transmission
GO:0007416 synapse assembly
GO:0007420 brain development
GO:0007585 respiratory gaseous exchange
GO:0007612 learning
GO:0007613 memory
GO:0007616 long-term memory
GO:0008104 protein localization
GO:0008211 glucocorticoid metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0008344 adult locomotory behavior
GO:0008542 visual learning
GO:0009405 pathogenesis
GO:0009791 post-embryonic development
GO:0010468 regulation of gene expression
GO:0016358 dendrite development
GO:0016571 histone methylation
GO:0016573 histone acetylation
GO:0019230 proprioception
GO:0019233 sensory perception of pain
GO:0021549 cerebellum development
GO:0021591 ventricular system development
GO:0030182 neuron differentiation
GO:0031061 negative regulation of histone methylation
GO:0031175 neuron projection development
GO:0032048 cardiolipin metabolic process
GO:0033555 multicellular organismal response to stress
GO:0035067 negative regulation of histone acetylation
GO:0035176 social behavior
GO:0040029 regulation of gene expression, epigenetic
GO:0042551 neuron maturation
GO:0043524 negative regulation of neuron apoptotic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046470 phosphatidylcholine metabolic process
GO:0048167 regulation of synaptic plasticity
GO:0050432 catecholamine secretion
GO:0050884 neuromuscular process controlling posture
GO:0050905 neuromuscular process
GO:0051965 positive regulation of synapse assembly
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0060291 long-term synaptic potentiation
Cellular Component
GO:0000792 heterochromatin
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000169057
View Gene Order
ENSMUSG00000031393
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G3MYE7
UniProt Splice Variant
Entrez Gene 539629
UniGene Bt.11246
RefSeq NM_001206552
HUGO HGNC:6990
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02070090 DAAA02070091
GenPept
RNA Seq Atlas 539629
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca