InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: IL17F

Summary

InnateDB Gene

IDBG-632624.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL17F

Gene Name

interleukin-17F precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016835

Encoded Proteins

IDBP-684254

interleukin 17F

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 19144317

[Homo sapiens] IL17A and IL17F are required for the induction of beta-defensin in vivo in mice.

PMID 19244213

[Homo sapiens] IL17F signalling inhibits expression of pro-inflammatory genes though sequential phosphorylation of CEBPB regulatory 2 domain.

PMID 21074482

[Homo sapiens] IL17F is a Th17-related cytokine, traditionally thought of as an adaptive responder, has been shown to have various innate sources and functions as a rapidly produced pro-inflammatory mediator. Innate IL17F-producing cells also employ many of the cytokine and transcriptional regulators utilized by Th17 cells.

PMID 25595775

[Mus musculus] Defb1 is important for the control of early mucosal Candida infection and plays a critical role in the induction of innate inflammatory mediators including, Il1b, Il6, Cxcl1, Il17a, and Il17f.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112116:
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:24390407-24397956

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000022393

ENSBTAP00000022393

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0019955	cytokine binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006029	proteoglycan metabolic process
GO:0006954	inflammatory response
GO:0016525	negative regulation of angiogenesis
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0042089	cytokine biosynthetic process
GO:0042109	lymphotoxin A biosynthetic process
GO:0045076	regulation of interleukin-2 biosynthetic process
GO:0045408	regulation of interleukin-6 biosynthetic process
GO:0045414	regulation of interleukin-8 biosynthetic process
GO:0045423	regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051216	cartilage development
GO:1900017	positive regulation of cytokine production involved in inflammatory response

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000112116

View Gene Order

ENSMUSG00000041872

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

il23pathway

IL23-mediated signaling events

Cross-References

SwissProt

TrEMBL

F1MLN4

UniProt Splice Variant

Entrez Gene

506030

UniGene

Bt.22668

RefSeq

NM_001192082 XM_005223394

HUGO

HGNC:16404

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02055263

GenPept

RNA Seq Atlas

506030