Bos taurus Gene: MLL2 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Gene | IDBG-632681.3 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | MLL2 | ||||||||||||||
Gene Name | Uncharacterized protein | ||||||||||||||
Synonyms | MLL2 | ||||||||||||||
Species | Bos taurus | ||||||||||||||
Ensembl Gene | ENSBTAG00000014429 | ||||||||||||||
Encoded Proteins |
myeloid/lymphoid or mixed-lineage leukemia 2
myeloid/lymphoid or mixed-lineage leukemia 2
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Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
Entrez Gene | |||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167548:
The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome. [provided by RefSeq, Oct 2010] |
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Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 5:30931917-30964080 | ||||||||||||||
Strand | Forward strand | ||||||||||||||
Band | |||||||||||||||
Transcripts |
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Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME |
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
deactivation of the beta-catenin transactivating complex pathway
Signal Transduction pathway
TCF dependent signaling in response to WNT pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
formation of the beta-catenin:TCF transactivating complex pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Disease pathway
Disease pathway
Signaling by Wnt pathway
Signaling by WNT in cancer pathway
deactivation of the beta-catenin transactivating complex pathway
formation of the beta-catenin:TCF transactivating complex pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF dependent signaling in response to WNT pathway
Signal Transduction pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
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KEGG |
Lysine degradation pathway
Lysine degradation pathway
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INOH | |||||||||||||||
PID NCI | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | |||||||||||||||
TrEMBL | E1B9N8 G3MZF2 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 506805 | ||||||||||||||
UniGene | |||||||||||||||
RefSeq | |||||||||||||||
HUGO | HGNC:7133 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | DAAA02012952 | ||||||||||||||
GenPept | |||||||||||||||
RNA Seq Atlas | 506805 | ||||||||||||||