InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MAP4K3

Summary

InnateDB Gene

IDBG-632787.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP4K3

Gene Name

mitogen-activated protein kinase kinase kinase kinase 3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016442

Encoded Proteins

IDBP-684463

mitogen-activated protein kinase kinase kinase kinase 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000011566:
This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:21579432-21761348

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000061256

ENSBTAP00000053863

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000165	MAPK cascade
GO:0000185	activation of MAPKKK activity
GO:0006468	protein phosphorylation
GO:0009411	response to UV
GO:0016310	phosphorylation
GO:0034612	response to tumor necrosis factor
GO:0035556	intracellular signal transduction
GO:0050790	regulation of catalytic activity