Version 5.4
Bos taurus Gene: CAV1
Summary
InnateDB Gene IDBG-632834.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAV1
Gene Name Caveolin-1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017869
Encoded Proteins
IDBP-684491
Caveolin-1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19949109
[Homo sapiens] CAV1 is an important component of the innate host immune response to the majority of non-cytotoxic strains of P. aeruginosa by promoting bacterial clearance during acute pneumonia and chronic colonization.
PMID 20304961
[Homo sapiens] CAV1 is a scaffolding protein of caveolae that plays an important role in host defence and inflammation and CAV1 deficiency dampens Toll-like receptor 4 signalling through NOS3 (eNOS) activation.
PMID 19949109
[Mus musculus] Cav1 is an important component of the innate host immune response to the majority of non-cytotoxic strains of P. aeruginosa by promoting bacterial clearance during acute pneumonia and chronic colonization.
PMID 25665524
[Mus musculus] The Akt1/Mir199a/Cav1 pathway is a regulator of innate immunity that is dysfunctional in cystic fibrosis macrophages contributing to lung hyper-inflammation.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105974:
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:52173110-52208687
Strand Reverse strand
Band
Transcripts
ENSBTAT00000023751 ENSBTAP00000023751
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 115 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 115 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0016504 peptidase activator activity
GO:0019899 enzyme binding
GO:0050998 nitric-oxide synthase binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000165 MAPK cascade
GO:0000188 inactivation of MAPK activity
GO:0001525 angiogenesis
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0002026 regulation of the force of heart contraction
GO:0002931 response to ischemia
GO:0003057 regulation of the force of heart contraction by chemical signal
GO:0006641 triglyceride metabolic process
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006940 regulation of smooth muscle contraction
GO:0007519 skeletal muscle tissue development
GO:0007595 lactation
GO:0008104 protein localization
GO:0008150 biological_process
GO:0008285 negative regulation of cell proliferation
GO:0009267 cellular response to starvation
GO:0009968 negative regulation of signal transduction
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0010952 positive regulation of peptidase activity
GO:0016050 vesicle organization
GO:0019217 regulation of fatty acid metabolic process
GO:0019915 lipid storage
GO:0030193 regulation of blood coagulation
GO:0030514 negative regulation of BMP signaling pathway
GO:0030857 negative regulation of epithelial cell differentiation
GO:0030879 mammary gland development
GO:0031295 T cell costimulation
GO:0031397 negative regulation of protein ubiquitination
GO:0032091 negative regulation of protein binding
GO:0032570 response to progesterone
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033484 nitric oxide homeostasis
GO:0042310 vasoconstriction
GO:0042524 negative regulation of tyrosine phosphorylation of Stat5 protein
GO:0042632 cholesterol homeostasis
GO:0043407 negative regulation of MAP kinase activity
GO:0043409 negative regulation of MAPK cascade
GO:0043627 response to estrogen
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045907 positive regulation of vasoconstriction
GO:0046426 negative regulation of JAK-STAT cascade
GO:0048550 negative regulation of pinocytosis
GO:0048554 positive regulation of metalloenzyme activity
GO:0051001 negative regulation of nitric-oxide synthase activity
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0051480 cytosolic calcium ion homeostasis
GO:0051592 response to calcium ion
GO:0051899 membrane depolarization
GO:0052547 regulation of peptidase activity
GO:0055074 calcium ion homeostasis
GO:0060056 mammary gland involution
GO:0070836 caveola assembly
GO:0071455 cellular response to hyperoxia
GO:0072584 caveolin-mediated endocytosis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097190 apoptotic signaling pathway
GO:2000286 receptor internalization involved in canonical Wnt receptor signaling pathway
GO:2000811 negative regulation of anoikis
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0002080 acrosomal membrane
GO:0005622 intracellular
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0005929 cilium
GO:0005938 cell cortex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0042383 sarcolemma
GO:0043234 protein complex
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000105974
View Gene Order
ENSMUSG00000007655
View Gene Order
Pathways
NETPATH
REACTOME
REACT_212636
Signaling by Wnt pathway
REACT_242703
Signaling by WNT in cancer pathway
REACT_208597
Cell surface interactions at the vascular wall pathway
REACT_217977
eNOS activation pathway
REACT_226967
NOSTRIN mediated eNOS trafficking pathway
REACT_226352
eNOS activation and regulation pathway
REACT_220341
Metabolism of nitric oxide pathway
REACT_217918
TCF dependent signaling in response to WNT pathway
REACT_211113
Basigin interactions pathway
REACT_234280
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_214027
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
REACT_246299
VEGFA-VEGFR2 Pathway pathway
REACT_212196
Hemostasis pathway
REACT_242720
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_214353
Signal Transduction pathway
REACT_236208
VEGFR2 mediated vascular permeability pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_209873
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_219139
Metabolism pathway
REACT_226693
Signaling by VEGF pathway
REACT_236591
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_207087
Disease pathway
REACT_213267
Lipid digestion, mobilization, and transport pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
REACTOME
REACT_12560
Basigin interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_494
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
REACT_12541
NOSTRIN mediated eNOS trafficking pathway
REACT_12477
eNOS activation pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_12389
eNOS activation and regulation pathway
REACT_11045
Signaling by Wnt pathway
REACT_12529
Signaling by VEGF pathway
REACT_12508
Metabolism of nitric oxide pathway
REACT_200610
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_228016
VEGFR2 mediated vascular permeability pathway
REACT_111102
Signal Transduction pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_111217
Metabolism pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_602
Lipid digestion, mobilization, and transport pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
REACT_245618
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway
REACT_189085
Disease pathway
REACT_224553
Hemostasis pathway
REACT_214014
Signaling by Wnt pathway
REACT_204801
eNOS activation and regulation pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_221264
eNOS activation pathway
REACT_215995
NOSTRIN mediated eNOS trafficking pathway
REACT_227951
Signaling by VEGF pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_188937
Metabolism pathway
REACT_211508
Basigin interactions pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_238381
Lipid digestion, mobilization, and transport pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_216784
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_261840
VEGFR2 mediated vascular permeability pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_208364
Metabolism of nitric oxide pathway
REACT_188257
Signal Transduction pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
hsa04510
Focal adhesion pathway
hsa04144
Endocytosis pathway
hsa05416
Viral myocarditis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
mmu04510
Focal adhesion pathway
mmu04144
Endocytosis pathway
mmu05416
Viral myocarditis pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
INOH website
Integrin signaling pathway pathway
INOH website
Integrin signaling pathway pathway
PID NCI
tnfpathway
TNF receptor signaling pathway
ptp1bpathway
Signaling events mediated by PTP1B
p53downstreampathway
Direct p53 effectors
alk1pathway
ALK1 signaling events
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
wnt_canonical_pathway
Canonical Wnt signaling pathway
tgfbrpathway
TGF-beta receptor signaling
vegfr1_pathway
VEGFR1 specific signals
pdgfrapathway
PDGFR-alpha signaling pathway
insulin_pathway
Insulin Pathway
Cross-References
SwissProt P79132
TrEMBL
UniProt Splice Variant
Entrez Gene 281040
UniGene Bt.102005 Bt.106571 Bt.51574
RefSeq NM_174004 XM_005205391 XM_005205392
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY823915 DP000008 U86639
GenPept AAB47274 AAR16256 AAV83691
RNA Seq Atlas 281040

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca