Version 5.4
Bos taurus Gene: SENP1
Summary
InnateDB Gene IDBG-632901.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SENP1
Gene Name sentrin-specific protease 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012423
Encoded Proteins
IDBP-684592
SUMO1/sentrin specific peptidase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000079387:
This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:32363553-32407690
Strand Forward strand
Band
Transcripts
ENSBTAT00000045915 ENSBTAP00000043264
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
GO:0016929 SUMO-specific protease activity
Biological Process
GO:0006508 proteolysis
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010724 regulation of definitive erythrocyte differentiation
GO:0016926 protein desumoylation
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005925 focal adhesion
GO:0031965 nuclear membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000079387
View Gene Order
ENSMUSG00000033075
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_22161
Post-translational protein modification pathway
REACT_163793
Processing and activation of SUMO pathway
REACT_17015
Metabolism of proteins pathway
REACT_163725
SUMO is proteolytically processed pathway
REACT_163823
SUMOylation pathway
REACT_196649
SUMO is proteolytically processed pathway
REACT_196652
SUMOylation pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_196651
Processing and activation of SUMO pathway
KEGG
INOH
PID NCI
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.81171
RefSeq NM_001206876
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca