InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HDAC7

Summary

InnateDB Gene

IDBG-633011.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HDAC7

Gene Name

histone deacetylase 7

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000026819

Encoded Proteins

IDBP-684677

histone deacetylase 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000061273:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:32635940-32667499

Strand

Forward strand

Band

Transcripts

ENSBTAT00000038321

ENSBTAP00000038136

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 106 interaction(s) predicted by orthology.

Predicted by orthology
Total	106 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003714	transcription corepressor activity
GO:0004407	histone deacetylase activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0019901	protein kinase binding
GO:0033613	activating transcription factor binding
GO:0070491	repressing transcription factor binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001570	vasculogenesis
GO:0007043	cell-cell junction assembly
GO:0008152	metabolic process
GO:0016568	chromatin modification
GO:0016575	histone deacetylation
GO:0032703	negative regulation of interleukin-2 production
GO:0045668	negative regulation of osteoblast differentiation
GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis