Version 5.4
Bos taurus Gene: FARP1
Summary
InnateDB Gene IDBG-633077.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FARP1
Gene Name FERM, RhoGEF and pleckstrin domain-containing protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000146
Encoded Proteins
IDBP-684763
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152767:
This gene was originally isolated through subtractive hybridization due to its increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the band 4.1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a protein containing a FERM (4.2, exrin, radixin, moesin) domain, a Dbl homology domain, and two pleckstrin homology domains. These domains are found in guanine nucleotide exchange factors and proteins that link the cytoskeleton to the cell membrane. The encoded protein functions in neurons to promote dendritic growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:79189512-79429462
Strand Forward strand
Band
Transcripts
ENSBTAT00000000167 ENSBTAP00000000167
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0008092 cytoskeletal protein binding
Biological Process
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0019898 extrinsic component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000152767
View Gene Order
ENSMUSG00000025555
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
rhoa_reg_pathway
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL F1MFC6
UniProt Splice Variant
Entrez Gene 782949
UniGene Bt.47429
RefSeq NM_001192712 XM_001250661 XM_005213945 XM_005213946
HUGO HGNC:3591
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02034710 DAAA02034711 DAAA02034712
GenPept
RNA Seq Atlas 531927 782949

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca