InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.105466

Summary

InnateDB Gene

IDBG-633090.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.105466

Gene Name

serine/threonine-protein kinase 24

Synonyms

MST3B

Species

Bos taurus

Ensembl Gene

ENSBTAG00000032234

Encoded Proteins

IDBP-684779

serine/threonine-protein kinase 24

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102572:
The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000 [PubMed 10644707]).[supplied by OMIM, Mar 2008]
This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:79432789-79483799

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000026195

ENSBTAP00000026195

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.

Predicted by orthology
Total	53 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0023014	signal transduction by phosphorylation
GO:0030336	negative regulation of cell migration
GO:0046777	protein autophosphorylation
GO:0048679	regulation of axon regeneration
GO:0097194	execution phase of apoptosis

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000102572

View Gene Order

ENSMUSG00000063410

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_107

Apoptotic cleavage of cellular proteins pathway

REACT_995

Apoptotic execution phase pathway

REACT_578

Apoptosis pathway

REACT_258521

Apoptosis pathway

REACT_207035

Apoptotic execution phase pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

F1N5S6

UniProt Splice Variant

Entrez Gene

101906511

UniGene

Bt.105466 Bt.65243

RefSeq

NM_001099950

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02034712 DAAA02034713

GenPept

RNA Seq Atlas

100101492 101906511