Version 5.4
Homo sapiens Gene: TMPRSS6
Summary
InnateDB Gene IDBG-6331.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMPRSS6
Gene Name transmembrane protease, serine 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000187045
Encoded Proteins
IDBP-6333
transmembrane protease, serine 6
IDBP-6335
transmembrane protease, serine 6
IDBP-293897
transmembrane protease, serine 6
IDBP-293900
transmembrane protease, serine 6
IDBP-375157
transmembrane protease, serine 6
IDBP-375166
transmembrane protease, serine 6
IDBP-375168
transmembrane protease, serine 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:37065436-37109563
Strand Reverse strand
Band q12.3
Transcripts
ENST00000346753 ENSP00000334962
ENST00000381792 ENSP00000371211
ENST00000406725 ENSP00000385453
ENST00000406856 ENSP00000384964
ENST00000429068 ENSP00000392433
ENST00000442782 ENSP00000397691
ENST00000423761 ENSP00000400317
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0006508 proteolysis
GO:0030198 extracellular matrix organization
GO:0035556 intracellular signal transduction
GO:0042730 fibrinolysis
GO:0055072 iron ion homeostasis
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000016942
View Gene Order
ENSBTAG00000032152
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.370885
RefSeq NM_001289000 NM_001289001 NM_153609 XM_006724162 XM_006724163
HUGO
OMIM
CCDS CCDS13941 CCDS74856 CCDS74857
HPRD 10270
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca