InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PAFAH1B1

Summary

InnateDB Gene

IDBG-633101.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAFAH1B1

Gene Name

platelet-activating factor acetylhydrolase IB subunit alpha

Synonyms

LIS-1; LIS1; MDCR

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016806

Encoded Proteins

IDBP-684798

platelet-activating factor acetylhydrolase IB subunit alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000007168:
This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum. [provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:24088805-24158415

Strand

Forward strand

Band

Transcripts

ENSBTAT00000055329

ENSBTAP00000052656

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0042803	protein homodimerization activity
GO:0045502	dynein binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0000226	microtubule cytoskeleton organization
GO:0001667	ameboidal cell migration
GO:0001675	acrosome assembly
GO:0001764	neuron migration
GO:0001961	positive regulation of cytokine-mediated signaling pathway
GO:0006629	lipid metabolic process
GO:0006810	transport
GO:0006928	cellular component movement
GO:0007017	microtubule-based process
GO:0007049	cell cycle
GO:0007067	mitotic nuclear division
GO:0007268	synaptic transmission
GO:0007275	multicellular organismal development
GO:0007399	nervous system development
GO:0007405	neuroblast proliferation
GO:0007611	learning or memory
GO:0008090	retrograde axon cargo transport
GO:0008344	adult locomotory behavior
GO:0009306	protein secretion
GO:0016042	lipid catabolic process
GO:0016477	cell migration
GO:0019226	transmission of nerve impulse
GO:0021540	corpus callosum morphogenesis
GO:0021766	hippocampus development
GO:0021819	layer formation in cerebral cortex
GO:0021987	cerebral cortex development
GO:0030036	actin cytoskeleton organization
GO:0030154	cell differentiation
GO:0031023	microtubule organizing center organization
GO:0032319	regulation of Rho GTPase activity
GO:0036035	osteoclast development
GO:0046329	negative regulation of JNK cascade
GO:0047496	vesicle transport along microtubule
GO:0048854	brain morphogenesis
GO:0050885	neuromuscular process controlling balance
GO:0051081	nuclear envelope disassembly
GO:0051301	cell division

Cellular Component

GO:0000235	astral microtubule
GO:0000776	kinetochore
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0005819	spindle
GO:0005856	cytoskeleton
GO:0005874	microtubule
GO:0005875	microtubule associated complex
GO:0005938	cell cortex
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0031252	cell leading edge
GO:0031512	motile primary cilium
GO:0031965	nuclear membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome