Version 5.4
Homo sapiens Gene: KCNH6
Summary
InnateDB Gene IDBG-63321.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNH6
Gene Name potassium voltage-gated channel, subfamily H (eag-related), member 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000173826
Encoded Proteins
IDBP-63325
potassium voltage-gated channel, subfamily H (eag-related), member 6
IDBP-382905
potassium voltage-gated channel, subfamily H (eag-related), member 6
IDBP-762668
IDBP-760982
IDBP-762378
IDBP-760511
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:63523334-63548977
Strand Forward strand
Band q23.3
Transcripts
ENST00000314672 ENSP00000318212
ENST00000456941 ENSP00000396900
ENST00000581784 ENSP00000463830
ENST00000583023 ENSP00000463533
ENST00000583465 ENSP00000462417
ENST00000580652 ENSP00000464672
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005216 ion channel activity
GO:0005249 voltage-gated potassium channel activity
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006811 ion transport
GO:0007165 signal transduction
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001901
View Gene Order
ENSBTAG00000016613
Not yet available
Pathways
NETPATH
REACTOME
REACT_75770
Voltage gated Potassium channels pathway
REACT_13685
Neuronal System pathway
REACT_75908
Potassium Channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL J3KSC2
UniProt Splice Variant
Entrez Gene 81033
UniGene Hs.591177
RefSeq NM_001278919 NM_001278920 NM_030779 NM_173092
HUGO HGNC:18862
OMIM 608168
CCDS CCDS11638 CCDS11639 CCDS62290
HPRD 16294
IMGT
EMBL AC113554
GenPept
RNA Seq Atlas 81033

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca