Version 5.4
Bos taurus Gene: CARKL
Summary
InnateDB Gene IDBG-633258.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CARKL
Gene Name sedoheptulokinase
Synonyms CARKL
Species Bos taurus
Ensembl Gene ENSBTAG00000000829
Encoded Proteins
IDBP-684954
sedoheptulokinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197417:
The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:24933750-24951464
Strand Reverse strand
Band
Transcripts
ENSBTAT00000001095 ENSBTAP00000001095
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0050277 sedoheptulokinase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0009052 pentose-phosphate shunt, non-oxidative branch
GO:0016310 phosphorylation
GO:0035963 cellular response to interleukin-13
GO:0043030 regulation of macrophage activation
GO:0050727 regulation of inflammatory response
GO:0071222 cellular response to lipopolysaccharide
GO:0071353 cellular response to interleukin-4
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000197417
View Gene Order
ENSMUSG00000005951
View Gene Order
Cross-References
SwissProt
TrEMBL Q1JPE3
UniProt Splice Variant
Entrez Gene 511999
UniGene Bt.14637
RefSeq NM_001075548
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT025410 DAAA02048691
GenPept ABF57366
RNA Seq Atlas 511999

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca