InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: VPS45

Summary

InnateDB Gene

IDBG-633450.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPS45

Gene Name

vacuolar protein sorting-associated protein 45

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020635

Encoded Proteins

IDBP-685162

vacuolar protein sorting-associated protein 45

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23738510

[Homo sapiens] Mutations in VPS45 are associated with congenital neutrophil defect syndrome.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136631:
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. [provided by RefSeq, Jul 2008]
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:20534021-20600696

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000027499

ENSBTAP00000027499

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006904	vesicle docking involved in exocytosis
GO:0016192	vesicle-mediated transport

Cellular Component

GO:0000139	Golgi membrane
GO:0010008	endosome membrane

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000136631

View Gene Order

ENSMUSG00000015747

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_24970

Factors involved in megakaryocyte development and platelet production pathway

REACT_604

Hemostasis pathway

REACT_224553

Hemostasis pathway

REACT_198649

Factors involved in megakaryocyte development and platelet production pathway

KEGG

hsa04144

Endocytosis pathway

mmu04144

Endocytosis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.13692

RefSeq

NM_001083501 XM_005203930

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas