Version 5.4
Bos taurus Gene: BT.49451
Summary
InnateDB Gene IDBG-633548.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.49451
Gene Name corticosteroid 11-beta-dehydrogenase isozyme 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005685
Encoded Proteins
IDBP-685270
corticosteroid 11-beta-dehydrogenase isozyme 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176387:
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:35159766-35165470
Strand Forward strand
Band
Transcripts
ENSBTAT00000007470 ENSBTAP00000007470
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016491 oxidoreductase activity
Biological Process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000176387
View Gene Order
ENSMUSG00000031891
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00140
Steroid hormone biosynthesis pathway
hsa04960
Aldosterone-regulated sodium reabsorption pathway
mmu00140
Steroid hormone biosynthesis pathway
mmu04960
Aldosterone-regulated sodium reabsorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1N3U0
UniProt Splice Variant
Entrez Gene 282434
UniGene Bt.49451
RefSeq NM_174642
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02046682
GenPept
RNA Seq Atlas 282434

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca