Version 5.4
Bos taurus Gene: HOXA1
Summary
InnateDB Gene IDBG-633601.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOXA1
Gene Name homeobox protein Hox-A1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013263
Encoded Proteins
IDBP-685316
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105991:
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:69401001-69402503
Strand Forward strand
Band
Transcripts
ENSBTAT00000001367 ENSBTAP00000001367
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.
Predicted by orthology
Total 64 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007399 nervous system development
GO:0007605 sensory perception of sound
GO:0007634 optokinetic behavior
GO:0008045 motor neuron axon guidance
GO:0009653 anatomical structure morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0021569 rhombomere 3 development
GO:0021570 rhombomere 4 development
GO:0021571 rhombomere 5 development
GO:0021599 abducens nerve formation
GO:0021612 facial nerve structural organization
GO:0021754 facial nucleus development
GO:0021953 central nervous system neuron differentiation
GO:0030902 hindbrain development
GO:0042472 inner ear morphogenesis
GO:0042473 outer ear morphogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048702 embryonic neurocranium morphogenesis
GO:0048839 inner ear development
GO:0048844 artery morphogenesis
GO:0050795 regulation of behavior
GO:0050890 cognition
GO:0050905 neuromuscular process
GO:0060840 artery development
GO:0060876 semicircular canal formation
GO:0090102 cochlea development
GO:0090103 cochlea morphogenesis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000105991
View Gene Order
ENSMUSG00000029844
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.112432
RefSeq NM_001206111
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca