InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GNE

Summary

InnateDB Gene

IDBG-633656.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNE

Gene Name

bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001142

Encoded Proteins

IDBP-685379

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159921:
The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:60873151-60905455

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000001520

ENSBTAP00000001520

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0005524	ATP binding
GO:0008761	UDP-N-acetylglucosamine 2-epimerase activity
GO:0009384	N-acylmannosamine kinase activity
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006047	UDP-N-acetylglucosamine metabolic process
GO:0009103	lipopolysaccharide biosynthetic process
GO:0046380	N-acetylneuraminate biosynthetic process
GO:0046835	carbohydrate phosphorylation