Version 5.4
Bos taurus Gene: ERLEC1
Summary
InnateDB Gene IDBG-633833.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERLEC1
Gene Name endoplasmic reticulum lectin 1 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008068
Encoded Proteins
IDBP-685570
endoplasmic reticulum lectin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000068912:
This gene encodes a resident endoplasmic reticulum (ER) protein that functions in N-glycan recognition. This protein is thought to be involved in ER-associated degradation via its interaction with the membrane-associated ubiquitin ligase complex. It also functions as a regulator of multiple cellular stress-response pathways in a manner that promotes metastatic cell survival. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 21. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:36371087-36395686
Strand Forward strand
Band
Transcripts
ENSBTAT00000010613 ENSBTAP00000010613
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0005515 protein binding
Biological Process
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005788 endoplasmic reticulum lumen
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000068912
View Gene Order
ENSMUSG00000020311
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228190
Processing-defective Hh variants abrogate ligand secretion pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_111102
Signal Transduction pathway
REACT_228209
Hh ligand biogenesis disease pathway
REACT_228111
Hedgehog ligand biogenesis pathway
REACT_116125
Disease pathway
REACT_189085
Disease pathway
REACT_233316
Hedgehog ligand biogenesis pathway
REACT_248271
Processing-defective Hh variants abrogate ligand secretion pathway
REACT_232469
Hh ligand biogenesis disease pathway
REACT_250064
Signaling by Hedgehog pathway
REACT_188257
Signal Transduction pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MGK3
UniProt Splice Variant
Entrez Gene 781454
UniGene Bt.19941
RefSeq NM_001191407
HUGO HGNC:25222
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02030893
GenPept
RNA Seq Atlas 781454

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca