InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.31205

Summary

InnateDB Gene

IDBG-633885.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.31205

Gene Name

peroxisomal biogenesis factor 3

Synonyms

Peroxin-3

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001747

Encoded Proteins

IDBP-685630

peroxisomal biogenesis factor 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000034693:
The product of this gene is involved in peroxisome biosynthesis and integrity. It assembles membrane vesicles before the matrix proteins are translocated. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause Zellweger syndrome (ZWS). [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:81967633-81999683

Strand

Forward strand

Band

Transcripts

ENSBTAT00000002294

ENSBTAP00000002294

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0046983	protein dimerization activity

Biological Process

GO:0007031	peroxisome organization
GO:0045046	protein import into peroxisome membrane

Cellular Component

GO:0005634	nucleus
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005779	integral component of peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0016020	membrane
GO:0032994	protein-lipid complex
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex