InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: IGFBP3

Summary

InnateDB Gene

IDBG-633994.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGFBP3

Gene Name

Insulin-like growth factor-binding protein 3

Synonyms

IGFBP-3

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003994

Encoded Proteins

IDBP-685744

Insulin-like growth factor-binding protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146674:
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:76705105-76712709

Strand

Forward strand

Band

Transcripts

ENSBTAT00000053426

ENSBTAP00000047769

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding
GO:0008160	protein tyrosine phosphatase activator activity
GO:0019838	growth factor binding
GO:0031994	insulin-like growth factor I binding

Biological Process

GO:0001558	regulation of cell growth
GO:0001649	osteoblast differentiation
GO:0001933	negative regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0008285	negative regulation of cell proliferation
GO:0010906	regulation of glucose metabolic process
GO:0014912	negative regulation of smooth muscle cell migration
GO:0040008	regulation of growth
GO:0043065	positive regulation of apoptotic process
GO:0043085	positive regulation of catalytic activity
GO:0043410	positive regulation of MAPK cascade
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
GO:0044342	type B pancreatic cell proliferation
GO:0045663	positive regulation of myoblast differentiation
GO:0048662	negative regulation of smooth muscle cell proliferation