Bos taurus Gene: BT.35140 | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Gene | IDBG-634106.3 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | BT.35140 | ||||||||||||||||
Gene Name | tripeptidyl-peptidase 1 precursor | ||||||||||||||||
Synonyms | CLN2; TPP-1; TPP-I | ||||||||||||||||
Species | Bos taurus | ||||||||||||||||
Ensembl Gene | ENSBTAG00000015403 | ||||||||||||||||
Encoded Proteins |
tripeptidyl-peptidase 1 precursor
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Protein Structure | |||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
Entrez Gene | |||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166340:
This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||
Type | Protein coding | ||||||||||||||||
Genomic Location | Chromosome 15:47065387-47070711 | ||||||||||||||||
Strand | Forward strand | ||||||||||||||||
Band | |||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||
NETPATH | |||||||||||||||||
REACTOME |
XBP1(S) activates chaperone genes pathway
IRE1alpha activates chaperones pathway
Unfolded Protein Response (UPR) pathway
Metabolism of proteins pathway
Unfolded Protein Response (UPR) pathway
Metabolism of proteins pathway
IRE1alpha activates chaperones pathway
XBP1(S) activates chaperone genes pathway
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KEGG |
Lysosome pathway
Lysosome pathway
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INOH | |||||||||||||||||
PID NCI | |||||||||||||||||
Cross-References | |||||||||||||||||
SwissProt | |||||||||||||||||
TrEMBL | F1MK08 | ||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | 515575 | ||||||||||||||||
UniGene | Bt.35140 | ||||||||||||||||
RefSeq | NM_001075718 | ||||||||||||||||
HUGO | |||||||||||||||||
OMIM | |||||||||||||||||
CCDS | |||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
EMBL | DAAA02040852 DAAA02040853 | ||||||||||||||||
GenPept | |||||||||||||||||
RNA Seq Atlas | 515575 | ||||||||||||||||