Version 5.4
Bos taurus Gene: NPHP4
Summary
InnateDB Gene IDBG-634115.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPHP4
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008126
Encoded Proteins
IDBP-685914
nephronophthisis 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131697:
This gene encodes a protein involved in renal tubular development and function. This protein interacts with nephrocystin, and belongs to a multifunctional complex that is localized to actin- and microtubule-based structures. Mutations in this gene are associated with nephronophthisis type 4, a renal disease, and with Senior-Loken syndrome type 4, a combination of nephronophthisis and retinitis pigmentosa. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:48181539-48314477
Strand Forward strand
Band
Transcripts
ENSBTAT00000045440 ENSBTAP00000042828
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 169 interaction(s) predicted by orthology.
Predicted by orthology
Total 169 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0060041 retina development in camera-type eye
Cellular Component
GO:0005813 centrosome
GO:0005911 cell-cell junction
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000131697
View Gene Order
ENSMUSG00000039577
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118607
Signaling by Hippo pathway
REACT_111102
Signal Transduction pathway
REACT_196537
Signaling by Hippo pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BJB5
UniProt Splice Variant
Entrez Gene 519551
UniGene Bt.109803 Bt.109994 Bt.43355
RefSeq XM_002694114 XM_005217168 XM_005217169 XM_005217170 XM_005217171 XM_005217172 XM_005217173 XM_005217174 XM_005217175 XM_005217177
HUGO HGNC:19104
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02043092 DAAA02043093 DAAA02043094 DAAA02043095 DAAA02043096
GenPept
RNA Seq Atlas 519551

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca