Version 5.4
Bos taurus Gene: H2AFV
Summary
InnateDB Gene IDBG-634149.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol H2AFV
Gene Name Histone H2A.V
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000016975
Encoded Proteins
IDBP-685903
Histone H2A.V
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105968:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. Several transcript variants encoding different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:77389255-77401081
Strand Forward strand
Band
Transcripts
ENSBTAT00000022576 ENSBTAP00000022576
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000105968
View Gene Order
ENSMUSG00000041126
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_27235
Meiotic Recombination pathway
REACT_75800
Meiotic Synapsis pathway
REACT_200794
Mus musculus biological processes pathway
REACT_200667
NoRC negatively regulates rRNA expression pathway
REACT_198626
Meiotic synapsis pathway
REACT_188804
Cell Cycle pathway
REACT_214440
NoRC negatively regulates rRNA expression pathway
REACT_205737
Epigenetic regulation of gene expression pathway
REACT_233572
Gene Expression pathway
REACT_268475
DNA methylation pathway
REACT_207809
Negative epigenetic regulation of rRNA expression pathway
REACT_198624
Meiosis pathway
KEGG
hsa05322
Systemic lupus erythematosus pathway
mmu05322
Systemic lupus erythematosus pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.676
RefSeq NM_001038197
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca