Version 5.4
Bos taurus Gene: PNPT1
Summary
InnateDB Gene IDBG-634203.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PNPT1
Gene Name polyribonucleotide nucleotidyltransferase 1, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008909
Encoded Proteins
IDBP-685974
polyribonucleotide nucleotidyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138035:
The protein encoded by this gene belongs to the evolutionary conserved polynucleotide phosphorylase family comprised of phosphate dependent 3'-to-5' exoribonucleases implicated in RNA processing and degradation. This enzyme is predominantly localized in the mitochondrial intermembrane space and is involved in import of RNA to mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency-13 and autosomal recessive nonsyndromic deafness-70. Related pseudogenes are found on chromosomes 3 and 7. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:38161134-38200964
Strand Reverse strand
Band
Transcripts
ENSBTAT00000011729 ENSBTAP00000011729
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000175 3'-5'-exoribonuclease activity
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004654 polyribonucleotide nucleotidyltransferase activity
GO:0005515 protein binding
GO:0008266 poly(U) RNA binding
GO:0034046 poly(G) binding
GO:0035198 miRNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000957 mitochondrial RNA catabolic process
GO:0000958 mitochondrial mRNA catabolic process
GO:0000962 positive regulation of mitochondrial RNA catabolic process
GO:0000964 mitochondrial RNA 5'-end processing
GO:0000965 mitochondrial RNA 3'-end processing
GO:0006396 RNA processing
GO:0006401 RNA catabolic process
GO:0006402 mRNA catabolic process
GO:0034599 cellular response to oxidative stress
GO:0035458 cellular response to interferon-beta
GO:0035927 RNA import into mitochondrion
GO:0035928 rRNA import into mitochondrion
GO:0043457 regulation of cellular respiration
GO:0043631 RNA polyadenylation
GO:0045926 negative regulation of growth
GO:0051260 protein homooligomerization
GO:0061014 positive regulation of mRNA catabolic process
GO:0070207 protein homotrimerization
GO:0070584 mitochondrion morphogenesis
GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process
GO:0071850 mitotic cell cycle arrest
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:0097222 mitochondrial mRNA polyadenylation
GO:2000627 positive regulation of miRNA catabolic process
GO:2000772 regulation of cellular senescence
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0045025 mitochondrial degradosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000138035
View Gene Order
ENSMUSG00000020464
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00230
Purine metabolism pathway
hsa03018
RNA degradation pathway
mmu00240
Pyrimidine metabolism pathway
mmu00230
Purine metabolism pathway
mmu03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BIQ0
UniProt Splice Variant
Entrez Gene 508877
UniGene
RefSeq NM_001192197 XM_005212595
HUGO HGNC:23166
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02030914 DAAA02030915
GenPept
RNA Seq Atlas 508877

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca