InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: LEMD3

Summary

InnateDB Gene

IDBG-634335.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LEMD3

Gene Name

inner nuclear membrane protein Man1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000039435

Encoded Proteins

IDBP-686113

LEM domain containing 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174106:
This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.[provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:48773272-48844474

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000053178

ENSBTAP00000047700

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding

Biological Process

GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514	negative regulation of BMP signaling pathway
GO:0032926	negative regulation of activin receptor signaling pathway
GO:0035914	skeletal muscle cell differentiation
GO:0051726	regulation of cell cycle

Cellular Component

GO:0005635	nuclear envelope
GO:0005637	nuclear inner membrane
GO:0005639	integral component of nuclear inner membrane
GO:0016021	integral component of membrane