Version 5.4
Bos taurus Gene: SLC18A1
Summary
InnateDB Gene IDBG-634389.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC18A1
Gene Name chromaffin granule amine transporter
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020788
Encoded Proteins
IDBP-686170
solute carrier family 18 (vesicular monoamine), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000036565:
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:67724946-67781207
Strand Reverse strand
Band
Transcripts
ENSBTAT00000045811 ENSBTAP00000043172
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015238 drug transmembrane transporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006855 drug transmembrane transport
GO:0015893 drug transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000036565
View Gene Order
ENSMUSG00000036330
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20506
Na+/Cl- dependent neurotransmitter transporters pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_217615
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_253228
Na+/Cl- dependent neurotransmitter transporters pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
hsa05012
Parkinson's disease pathway
mmu05012
Parkinson's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MBH3
UniProt Splice Variant
Entrez Gene 617708
UniGene Bt.51028
RefSeq NM_001193171
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02023355 DAAA02023356 DAAA02023357 DAAA02023358 DAAA02023359
GenPept
RNA Seq Atlas 617708

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca