Version 5.4
Bos taurus Gene: BT.21198
Summary
InnateDB Gene IDBG-634401.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.21198
Gene Name cyclin-K
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018636
Encoded Proteins
IDBP-686206
Uncharacterized protein
IDBP-686209
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000090061:
The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:66159547-66174627
Strand Forward strand
Band
Transcripts
ENSBTAT00000063128 ENSBTAP00000055600
ENSBTAT00000024796 ENSBTAP00000024796
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity
GO:0019901 protein kinase binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001701 in utero embryonic development
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0071157 negative regulation of cell cycle arrest
Cellular Component
GO:0002944 cyclin K-CDK12 complex
GO:0002945 cyclin K-CDK13 complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000090061
View Gene Order
ENSMUSG00000021258
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt
TrEMBL G3N172
UniProt Splice Variant
Entrez Gene 530744
UniGene Bt.21198
RefSeq NM_001205981 XM_005222216 XM_005222217 XM_005222218
HUGO HGNC:1596
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02053215 DAAA02053216
GenPept
RNA Seq Atlas 530744

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca