Version 5.4
Bos taurus Gene: ALDH2
Summary
InnateDB Gene IDBG-634453.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALDH2
Gene Name Aldehyde dehydrogenase, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008743
Encoded Proteins
IDBP-686249
Aldehyde dehydrogenase, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111275:
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50%% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:64551612-64577901
Strand Reverse strand
Band
Transcripts
ENSBTAT00000011521 ENSBTAP00000011521
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004029 aldehyde dehydrogenase (NAD) activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Biological Process
GO:0006068 ethanol catabolic process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000111275
View Gene Order
ENSMUSG00000029455
View Gene Order
Pathways
NETPATH
REACTOME
REACT_223134
Neurotransmitter Clearance In The Synaptic Cleft pathway
REACT_223058
Transmission across Chemical Synapses pathway
REACT_226409
Phase 1 - Functionalization of compounds pathway
REACT_218176
Biological oxidations pathway
REACT_215931
Ethanol oxidation pathway
REACT_225032
Neuronal System pathway
REACT_219139
Metabolism pathway
REACT_227135
Metabolism of serotonin pathway
REACT_207961
Serotonin clearance from the synaptic cleft pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_34
Ethanol oxidation pathway
REACT_15532
Metabolism of serotonin pathway
REACT_13583
Neurotransmitter Clearance In The Synaptic Cleft pathway
REACT_13685
Neuronal System pathway
REACT_15391
Serotonin clearance from the synaptic cleft pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
REACT_249802
Phase 1 - Functionalization of compounds pathway
REACT_262153
Serotonin clearance from the synaptic cleft pathway
REACT_260489
Ethanol oxidation pathway
REACT_188937
Metabolism pathway
REACT_231054
Metabolism of serotonin pathway
REACT_251127
Neurotransmitter Clearance In The Synaptic Cleft pathway
REACT_259290
Neuronal System pathway
REACT_232343
Biological oxidations pathway
REACT_233318
Transmission across Chemical Synapses pathway
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00340
Histidine metabolism pathway
hsa00620
Pyruvate metabolism pathway
hsa00280
Valine, leucine and isoleucine degradation pathway
hsa00330
Arginine and proline metabolism pathway
hsa00380
Tryptophan metabolism pathway
hsa00040
Pentose and glucuronate interconversions pathway
hsa00071
Fatty acid degradation pathway
hsa00310
Lysine degradation pathway
hsa00053
Ascorbate and aldarate metabolism pathway
hsa00410
beta-Alanine metabolism pathway
hsa00561
Glycerolipid metabolism pathway
mmu00410
beta-Alanine metabolism pathway
mmu00280
Valine, leucine and isoleucine degradation pathway
mmu00340
Histidine metabolism pathway
mmu00053
Ascorbate and aldarate metabolism pathway
mmu00310
Lysine degradation pathway
mmu00010
Glycolysis / Gluconeogenesis pathway
mmu00330
Arginine and proline metabolism pathway
mmu00380
Tryptophan metabolism pathway
mmu00040
Pentose and glucuronate interconversions pathway
mmu00620
Pyruvate metabolism pathway
mmu00561
Glycerolipid metabolism pathway
mmu00071
Fatty acid degradation pathway
INOH
INOH website
Tryptophan degradation pathway
INOH website
Propanoate metabolism pathway
INOH website
Arginine Proline metabolism pathway
INOH website
Pyruvate metabolism pathway
INOH website
Valine Leucine Isoleucine degradation pathway
INOH website
Lysine degradation pathway
INOH website
Histidine degradation pathway
PID NCI
Cross-References
SwissProt P20000
TrEMBL
UniProt Splice Variant
Entrez Gene 508629
UniGene Bt.44041 Bt.89503
RefSeq NM_001075367 XM_005217772
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC116084
GenPept AAI16085
RNA Seq Atlas 508629

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca