Version 5.4
Bos taurus Gene: MDC1
Summary
InnateDB Gene IDBG-634528.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MDC1
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000025526
Encoded Proteins
IDBP-686329
mediator of DNA-damage checkpoint 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137337:
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:28117757-28127002
Strand Reverse strand
Band
Transcripts
ENSBTAT00000035900 ENSBTAP00000035767
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 166 interaction(s) predicted by orthology.
Predicted by orthology
Total 166 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008022 protein C-terminus binding
GO:0070975 FHA domain binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005925 focal adhesion
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000137337
View Gene Order
ENSMUSG00000061607
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_24
TSLP pathway
REACTOME
REACT_97
Recruitment of repair and signaling proteins to double-strand breaks pathway
REACT_1924
ATM mediated phosphorylation of repair proteins pathway
REACT_204
ATM mediated response to DNA double-strand break pathway
REACT_1874
Homologous Recombination Repair pathway
REACT_2054
Double-Strand Break Repair pathway
REACT_1587
Homologous recombination repair of replication-independent double-strand breaks pathway
REACT_216
DNA Repair pathway
REACT_251314
ATM mediated phosphorylation of repair proteins pathway
REACT_230172
Recruitment of repair and signaling proteins to double-strand breaks pathway
REACT_238355
Double-Strand Break Repair pathway
REACT_233397
DNA Repair pathway
REACT_245922
Homologous Recombination Repair pathway
REACT_237642
ATM mediated response to DNA double-strand break pathway
REACT_251264
Homologous recombination repair of replication-independent double-strand breaks pathway
KEGG
INOH
PID NCI
atm_pathway
ATM pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.57442
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca