InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GAS6

Summary

InnateDB Gene

IDBG-634586.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GAS6

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019964

Encoded Proteins

IDBP-686501

growth arrest-specific 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 11948660

[Homo sapiens] GAS6 is a ligand for all members of the TAM receptor tyrosine kinase family, each of which has different affinities to GAS6.

PMID 16723520

[Homo sapiens] GAS6 signals through the AXL receptor and the PI3-kinase/Akt1 survival pathway, protecting oligodendrocytes from growth factor withdrawal and TNF-alpha-mediated cell death.

PMID 22043818

[Homo sapiens] GAS6 works with PROS1 to synergistically suppress the basal and TLR-triggered production of inflammatory cytokines in macrophages. (Demonstrated in mice)

PMID 22043818

[Mus musculus] Gas6 works with Pros1 to synergistically suppress the basal and TLR-triggered production of inflammatory cytokines in macrophages.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183087:
This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation, and may play a role in thrombosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:90821803-90850163

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000035307

ENSBTAP00000035185

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001786	phosphatidylserine binding
GO:0005102	receptor binding
GO:0005245	voltage-gated calcium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0030296	protein tyrosine kinase activator activity
GO:0030971	receptor tyrosine kinase binding
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0048018	receptor agonist activity
GO:0060090	binding, bridging

Biological Process

GO:0001764	neuron migration
GO:0001934	positive regulation of protein phosphorylation
GO:0001961	positive regulation of cytokine-mediated signaling pathway
GO:0003104	positive regulation of glomerular filtration
GO:0006468	protein phosphorylation
GO:0006909	phagocytosis
GO:0007165	signal transduction
GO:0007167	enzyme linked receptor protein signaling pathway
GO:0007596	blood coagulation
GO:0009267	cellular response to starvation
GO:0010628	positive regulation of gene expression
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010934	macrophage cytokine production
GO:0018105	peptidyl-serine phosphorylation
GO:0019064	fusion of virus membrane with host plasma membrane
GO:0019079	viral genome replication
GO:0031589	cell-substrate adhesion
GO:0032008	positive regulation of TOR signaling
GO:0032148	activation of protein kinase B activity
GO:0032689	negative regulation of interferon-gamma production
GO:0032715	negative regulation of interleukin-6 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0032825	positive regulation of natural killer cell differentiation
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0033159	negative regulation of protein import into nucleus, translocation
GO:0035457	cellular response to interferon-alpha
GO:0035690	cellular response to drug
GO:0035754	B cell chemotaxis
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043277	apoptotic cell clearance
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043491	protein kinase B signaling
GO:0045860	positive regulation of protein kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046718	viral entry into host cell
GO:0046813	receptor-mediated virion attachment to host cell
GO:0046827	positive regulation of protein export from nucleus
GO:0048146	positive regulation of fibroblast proliferation
GO:0050711	negative regulation of interleukin-1 secretion
GO:0050766	positive regulation of phagocytosis
GO:0051897	positive regulation of protein kinase B signaling
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:0070168	negative regulation of biomineral tissue development
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070588	calcium ion transmembrane transport
GO:0071307	cellular response to vitamin K
GO:0071333	cellular response to glucose stimulus
GO:0071363	cellular response to growth factor stimulus
GO:0072661	protein targeting to plasma membrane
GO:0085029	extracellular matrix assembly
GO:0097028	dendritic cell differentiation
GO:0097241	hematopoietic stem cell migration to bone marrow
GO:1900142	negative regulation of oligodendrocyte apoptotic process
GO:1900165	negative regulation of interleukin-6 secretion
GO:2000270	negative regulation of fibroblast apoptotic process
GO:2000352	negative regulation of endothelial cell apoptotic process
GO:2000510	positive regulation of dendritic cell chemotaxis
GO:2000533	negative regulation of renal albumin absorption
GO:2000669	negative regulation of dendritic cell apoptotic process