InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MASP1

Summary

InnateDB Gene

IDBG-634626.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MASP1

Gene Name

mannan-binding lectin serine protease 1 precursor

Synonyms

RPIB9

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012467

Encoded Proteins

IDBP-686401

mannan-binding lectin serine protease 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20038603

[Homo sapiens] MASP1 is an essential protease of both the lectin and alternative complement pathways, essential components of innate immunity, participating in the pathogenesis of inflammatory diseases and in host defence.

PMID 22966085

[Homo sapiens] MASP1 is crucial for classical complement activation, but is not required for the alternative pathway function.

PMID 23785123

[Homo sapiens] MASP1 forms a complex with MASP2 to activate the complement system.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127241:
This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:80596924-80649363

Strand

Forward strand

Band

Transcripts

ENSBTAT00000016545

ENSBTAP00000016545

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0016787	hydrolase activity
GO:0042803	protein homodimerization activity
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0001867	complement activation, lectin pathway
GO:0006508	proteolysis
GO:0006956	complement activation
GO:0045916	negative regulation of complement activation