Version 5.4
Bos taurus Gene: BT.24636
Summary
InnateDB Gene IDBG-634701.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.24636
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019354
Encoded Proteins
IDBP-686513
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125618:
This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:46785772-46812769
Strand Reverse strand
Band
Transcripts
ENSBTAT00000025783 ENSBTAP00000025783
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0007417 central nervous system development
GO:0030154 cell differentiation
GO:0030878 thyroid gland development
GO:0039003 pronephric field specification
GO:0042472 inner ear morphogenesis
GO:0042981 regulation of apoptotic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048793 pronephros development
GO:0071371 cellular response to gonadotropin stimulus
GO:0071599 otic vesicle development
GO:0072050 S-shaped body morphogenesis
GO:0072073 kidney epithelium development
GO:0072108 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0072164 mesonephric tubule development
GO:0072207 metanephric epithelium development
GO:0072221 metanephric distal convoluted tubule development
GO:0072278 metanephric comma-shaped body morphogenesis
GO:0072284 metanephric S-shaped body morphogenesis
GO:0072289 metanephric nephron tubule formation
GO:0072305 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:1900212 negative regulation of mesenchymal cell apoptotic process involved in metanephros development
GO:1900215 negative regulation of apoptotic process involved in metanephric collecting duct development
GO:1900218 negative regulation of apoptotic process involved in metanephric nephron tubule development
GO:2000594 positive regulation of metanephric DCT cell differentiation
GO:2000611 positive regulation of thyroid hormone generation
GO:2000612 regulation of thyroid-stimulating hormone secretion
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000125618
View Gene Order
ENSMUSG00000026976
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_5
ID pathway
REACTOME
KEGG
hsa05216
Thyroid cancer pathway
hsa05200
Pathways in cancer pathway
mmu05216
Thyroid cancer pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MLH9
UniProt Splice Variant
Entrez Gene 534661
UniGene
RefSeq XM_002691400 XM_005192442 XM_005212815 XM_614504
HUGO HGNC:8622
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02031095
GenPept
RNA Seq Atlas 534661

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca