Version 5.4
Bos taurus Gene: PPP3CC
Summary
InnateDB Gene IDBG-634817.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP3CC
Gene Name serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020133
Encoded Proteins
IDBP-686617
serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120910:
Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:70262316-70341783
Strand Forward strand
Band
Transcripts
ENSBTAT00000026818 ENSBTAP00000026818
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0016787 hydrolase activity
Biological Process
GO:0008152 metabolic process
GO:0016311 dephosphorylation
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000120910
View Gene Order
ENSMUSG00000022092
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15334
DARPP-32 events pathway
REACT_15295
Opioid Signalling pathway
REACT_549
Activation of BAD and translocation to mitochondria pathway
REACT_14797
Signaling by GPCR pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_697
Activation of BH3-only proteins pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
REACT_258521
Apoptosis pathway
REACT_254215
Signaling by GPCR pathway
REACT_203795
DARPP-32 events pathway
REACT_221775
Activation of BAD and translocation to mitochondria pathway
REACT_212161
Activation of BH3-only proteins pathway
REACT_242845
Opioid Signalling pathway
REACT_188257
Signal Transduction pathway
REACT_204001
Intrinsic Pathway for Apoptosis pathway
KEGG
hsa04370
VEGF signaling pathway pathway
hsa04310
Wnt signaling pathway pathway
hsa04210
Apoptosis pathway
hsa04010
MAPK signaling pathway pathway
hsa04360
Axon guidance pathway
hsa04720
Long-term potentiation pathway
hsa05010
Alzheimer's disease pathway
hsa04662
B cell receptor signaling pathway pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa04020
Calcium signaling pathway pathway
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
hsa04114
Oocyte meiosis pathway
hsa04380
Osteoclast differentiation pathway
mmu04360
Axon guidance pathway
mmu04370
VEGF signaling pathway pathway
mmu04020
Calcium signaling pathway pathway
mmu05010
Alzheimer's disease pathway
mmu04660
T cell receptor signaling pathway pathway
mmu04310
Wnt signaling pathway pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu04010
MAPK signaling pathway pathway
mmu04720
Long-term potentiation pathway
mmu04210
Apoptosis pathway
mmu04662
B cell receptor signaling pathway pathway
mmu05014
Amyotrophic lateral sclerosis (ALS) pathway
mmu04114
Oocyte meiosis pathway
mmu04380
Osteoclast differentiation pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
CD4 T cell receptor signaling pathway
PID NCI
bcr_5pathway
BCR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.18218
RefSeq NM_001098076
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca