InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KIF13A

Summary

InnateDB Gene

IDBG-63485.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIF13A

Gene Name

kinesin family member 13A

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000137177

Encoded Proteins

IDBP-63487

kinesin family member 13A

IDBP-63489

kinesin family member 13A

IDBP-63491

kinesin family member 13A

IDBP-63495

kinesin family member 13A

IDBP-63497

kinesin family member 13A

IDBP-485198

kinesin family member 13A

IDBP-481844

kinesin family member 13A

IDBP-483007

kinesin family member 13A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:17759183-17987623

Strand

Reverse strand

Band

p22.3

Transcripts

ENST00000378843	ENSP00000368120
ENST00000378826	ENSP00000368103
ENST00000259711	ENSP00000259711
ENST00000378814	ENSP00000368091
ENST00000358380	ENSP00000351150
ENST00000502297	ENSP00000425616
ENST00000506044	ENSP00000422808
ENST00000514714
ENST00000503342
ENST00000507576
ENST00000505588
ENST00000502704	ENSP00000425453

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding

Biological Process

GO:0000910	cytokinesis
GO:0006886	intracellular protein transport
GO:0007018	microtubule-based movement
GO:0008152	metabolic process
GO:0008333	endosome to lysosome transport
GO:0032438	melanosome organization
GO:0035459	cargo loading into vesicle
GO:0043001	Golgi to plasma membrane protein transport
GO:0072383	plus-end-directed vesicle transport along microtubule

Cellular Component

GO:0000139	Golgi membrane
GO:0005813	centrosome
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0010008	endosome membrane
GO:0030496	midbody
GO:0032588	trans-Golgi network membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021375

View Gene Order

ENSBTAG00000019217

Not yet available

Pathways

NETPATH

REACTOME

REACT_16907

Association of TriC/CCT with target proteins during biosynthesis pathway

REACT_16952

Protein folding pathway

REACT_17004

Chaperonin-mediated protein folding pathway

REACT_17015

Metabolism of proteins pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.609743 Hs.629143 Hs.94499

RefSeq

NM_001105566 NM_001105567 NM_001105568 NM_001243423 NM_022113 XM_005249290 XM_005249294

HUGO

OMIM

CCDS

CCDS47380 CCDS47381 CCDS54967 CCDS54968 CCDS58998

HPRD

09256

IMGT

EMBL

GenPept

RNA Seq Atlas