InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.61430

Summary

InnateDB Gene

IDBG-634881.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.61430

Gene Name

25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016906

Encoded Proteins

IDBP-686685

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111012:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:56024278-56029202

Strand

Forward strand

Band

Transcripts

ENSBTAT00000022485

ENSBTAP00000022485

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0004498	calcidiol 1-monooxygenase activity
GO:0005506	iron ion binding
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0006816	calcium ion transport
GO:0008285	negative regulation of cell proliferation
GO:0010956	negative regulation of calcidiol 1-monooxygenase activity
GO:0010980	positive regulation of vitamin D 24-hydroxylase activity
GO:0030282	bone mineralization
GO:0030308	negative regulation of cell growth
GO:0030500	regulation of bone mineralization
GO:0032496	response to lipopolysaccharide
GO:0033280	response to vitamin D
GO:0034341	response to interferon-gamma
GO:0036378	calcitriol biosynthetic process from calciol
GO:0042359	vitamin D metabolic process
GO:0042369	vitamin D catabolic process
GO:0043627	response to estrogen
GO:0045618	positive regulation of keratinocyte differentiation
GO:0046697	decidualization
GO:0055074	calcium ion homeostasis
GO:0055114	oxidation-reduction process
GO:0070314	G1 to G0 transition
GO:0070564	positive regulation of vitamin D receptor signaling pathway