Version 5.4
Bos taurus Gene: RNF103
Summary
InnateDB Gene IDBG-634933.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF103
Gene Name E3 ubiquitin-protein ligase RNF103
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020947
Encoded Proteins
IDBP-686733
ring finger protein 103
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000239305:
The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:48149255-48171946
Strand Forward strand
Band
Transcripts
ENSBTAT00000027899 ENSBTAP00000027899
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
Orthologs
Species
Mus musculus
Homo sapiens
Gene ID
Gene Order
ENSMUSG00000052656
View Gene Order
ENSG00000239305
View Gene Order
Cross-References
SwissProt
TrEMBL E1BEJ4
UniProt Splice Variant
Entrez Gene 511639
UniGene Bt.14340
RefSeq NM_001191408
HUGO HGNC:12859
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02031122
GenPept
RNA Seq Atlas 511639

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca