Version 5.4
| Bos taurus Gene: EIF4G1 | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-635087.3 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | EIF4G1 | ||||||||||
| Gene Name | Uncharacterized protein | ||||||||||
| Synonyms | EIF4GI | ||||||||||
| Species | Bos taurus | ||||||||||
| Ensembl Gene | ENSBTAG00000012881 | ||||||||||
| Encoded Proteins |
eukaryotic translation initiation factor 4 gamma, 1
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| Protein Structure | |||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114867:
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010] The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5\'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010] |
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 1:83466847-83484338 | ||||||||||
| Strand | Reverse strand | ||||||||||
| Band | |||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH |
EGFR1 pathway
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| REACTOME |
ISG15 antiviral mechanism pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
S6K1 signalling pathway
S6K1-mediated signalling pathway
mTOR signalling pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
Deadenylation of mRNA pathway
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Translation initiation complex formation pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Ribosomal scanning and start codon recognition pathway
Eukaryotic Translation Initiation pathway
PKB-mediated events pathway
Nonsense-Mediated Decay (NMD) pathway
Deadenylation-dependent mRNA decay pathway
Antiviral mechanism by IFN-stimulated genes pathway
Cytokine Signaling in Immune system pathway
mTORC1-mediated signalling pathway
Translation pathway
Signal Transduction pathway
Interferon Signaling pathway
IRS-mediated signalling pathway
Metabolism of proteins pathway
Immune System pathway
Insulin receptor signalling cascade pathway
Cap-dependent Translation Initiation pathway
IRS-related events pathway
IGF1R signaling cascade pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Gene Expression pathway
Signaling by Insulin receptor pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
S6K1 signalling pathway
Cytokine Signaling in Immune system pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
Deadenylation of mRNA pathway
Translation pathway
Antiviral mechanism by IFN-stimulated genes pathway
ISG15 antiviral mechanism pathway
Immune System pathway
Translation initiation complex formation pathway
Nonsense-Mediated Decay (NMD) pathway
Metabolism of proteins pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
Cap-dependent Translation Initiation pathway
Eukaryotic Translation Initiation pathway
Insulin receptor signalling cascade pathway
S6K1-mediated signalling pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Interferon Signaling pathway
PI3K Cascade pathway
Gene Expression pathway
IRS-related events pathway
IRS-mediated signalling pathway
mTORC1-mediated signalling pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Signal Transduction pathway
Ribosomal scanning and start codon recognition pathway
mTOR signalling pathway
PKB-mediated events pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Deadenylation-dependent mRNA decay pathway
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| KEGG |
Viral myocarditis pathway
RNA transport pathway
Viral myocarditis pathway
RNA transport pathway
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| INOH |
Insulin receptor signaling pathway
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| PID NCI |
Validated targets of C-MYC transcriptional activation
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| Cross-References | |||||||||||
| SwissProt | |||||||||||
| TrEMBL | F1MX04 | ||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 444858 | ||||||||||
| UniGene | Bt.105671 Bt.29325 | ||||||||||
| RefSeq | XM_003585663 | ||||||||||
| HUGO | HGNC:3296 | ||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | DAAA02001883 DAAA02001884 | ||||||||||
| GenPept | |||||||||||
| RNA Seq Atlas | 444858 | ||||||||||