Version 5.4
Bos taurus Gene: TFB1M
Summary
InnateDB Gene IDBG-635120.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TFB1M
Gene Name Mitochondrial dimethyladenosine transferase 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000031895
Encoded Proteins
IDBP-686939
Mitochondrial dimethyladenosine transferase 1
IDBP-686940
Mitochondrial dimethyladenosine transferase 1
IDBP-686941
Mitochondrial dimethyladenosine transferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000029639:
The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID).[provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:93240604-93307575
Strand Reverse strand
Band
Transcripts
ENSBTAT00000045235 ENSBTAP00000042644
ENSBTAT00000045233 ENSBTAP00000042642
ENSBTAT00000065189 ENSBTAP00000054955
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008649 rRNA methyltransferase activity
GO:0016433 rRNA (adenine) methyltransferase activity
GO:0016740 transferase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000154 rRNA modification
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006364 rRNA processing
GO:0031167 rRNA methylation
GO:0032259 methylation
Cellular Component
GO:0005739 mitochondrion
GO:0042645 mitochondrial nucleoid
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000029639
View Gene Order
ENSMUSG00000036983
View Gene Order
Pathways
NETPATH
REACTOME
REACT_214581
Transcriptional activation of mitochondrial biogenesis pathway
REACT_205675
Mitochondrial biogenesis pathway
REACT_219259
Organelle biogenesis and maintenance pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
REACT_224594
Organelle biogenesis and maintenance pathway
REACT_205251
Transcriptional activation of mitochondrial biogenesis pathway
REACT_211261
Mitochondrial biogenesis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.56407
RefSeq NM_001076896 NM_001114610
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca