InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GSTM3

Summary

InnateDB Gene

IDBG-635275.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSTM3

Gene Name

glutathione S-transferase mu 3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001842

Encoded Proteins

IDBP-687107

glutathione S-transferase mu 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134202:
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual\'s susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:33768050-33770824

Strand

Forward strand

Band

Transcripts

ENSBTAT00000016865

ENSBTAP00000016865

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0005515	protein binding
GO:0016740	transferase activity
GO:0019899	enzyme binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043295	glutathione binding

Biological Process

GO:0006749	glutathione metabolic process
GO:0008152	metabolic process
GO:0018916	nitrobenzene metabolic process
GO:0042178	xenobiotic catabolic process
GO:0043627	response to estrogen
GO:0070458	cellular detoxification of nitrogen compound