InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: UBE2H

Summary

InnateDB Gene

IDBG-635401.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2H

Gene Name

Ubiquitin-conjugating enzyme E2 H

Synonyms

E2-20K; UBCH2

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000911

Encoded Proteins

IDBP-687239

Ubiquitin-conjugating enzyme E2 H

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186591:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100%% identical to the mouse homolog and 98%% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:94467623-94565768

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000001205

ENSBTAP00000001205

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.

Predicted by orthology
Total	61 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016874	ligase activity
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0016567	protein ubiquitination
GO:0070936	protein K48-linked ubiquitination
GO:0070979	protein K11-linked ubiquitination

Cellular Component

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000186591

View Gene Order

ENSMUSG00000039159

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

mmu04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Cross-References

SwissProt

Q32LN1

TrEMBL

UniProt Splice Variant

Entrez Gene

539313

UniGene

Bt.4543

RefSeq

NM_001037614

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC109502

GenPept

AAI09503

RNA Seq Atlas

539313