InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PTK2B

Summary

InnateDB Gene

IDBG-635661.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTK2B

Gene Name

protein-tyrosine kinase 2-beta

Synonyms

PYK2

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005958

Encoded Proteins

IDBP-687531

protein-tyrosine kinase 2-beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 10228162

[Homo sapiens] PTK2B mediates the JAK-dependent activation of MAPK and STAT1 in interferon (IFN)-gamma, but not IFN-alpha signalling.

PMID 14963038

[Homo sapiens] PTK2B amplifies epidermal growth factor receptor (EGFR) and SRC-induced STAT3 activation, implicating PTK2B activation as a potential co-mediator in triggering STAT3-induced oncogenesis.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120899:
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:75713097-75850738

Strand

Forward strand

Band

Transcripts

ENSBTAT00000007819

ENSBTAP00000007819

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.

Predicted by orthology
Total	80 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001954	positive regulation of cell-matrix adhesion
GO:0006468	protein phosphorylation
GO:0007166	cell surface receptor signaling pathway
GO:0007172	signal complex assembly
GO:0007229	integrin-mediated signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008360	regulation of cell shape
GO:0010595	positive regulation of endothelial cell migration
GO:0010976	positive regulation of neuron projection development
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030155	regulation of cell adhesion
GO:0030335	positive regulation of cell migration
GO:0030838	positive regulation of actin filament polymerization
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0042976	activation of Janus kinase activity
GO:0043066	negative regulation of apoptotic process
GO:0043267	negative regulation of potassium ion transport
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045860	positive regulation of protein kinase activity
GO:0046330	positive regulation of JNK cascade
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071300	cellular response to retinoic acid
GO:2000058	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process