InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ATP6V0A4

Summary

InnateDB Gene

IDBG-635934.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V0A4

Gene Name

V-type proton ATPase 116 kDa subunit a isoform 4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004263

Encoded Proteins

IDBP-687872

ATPase, H+ transporting, lysosomal V0 subunit a4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105929:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:103199966-103246668

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000005588

ENSBTAP00000005588

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0051117	ATPase binding

Biological Process

GO:0001503	ossification
GO:0006885	regulation of pH
GO:0007588	excretion
GO:0007605	sensory perception of sound
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport

Cellular Component

GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005903	brush border
GO:0016324	apical plasma membrane
GO:0016471	vacuolar proton-transporting V-type ATPase complex
GO:0031526	brush border membrane
GO:0033179	proton-transporting V-type ATPase, V0 domain
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome