Bos taurus Gene: MFN1 | |||||||||
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Summary | |||||||||
InnateDB Gene | IDBG-636012.3 | ||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
Gene Symbol | MFN1 | ||||||||
Gene Name | mitofusin-1 | ||||||||
Synonyms | MFN2 | ||||||||
Species | Bos taurus | ||||||||
Ensembl Gene | ENSBTAG00000010485 | ||||||||
Encoded Proteins |
mitofusin 1
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Protein Structure | |||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||
InnateDB Annotation from Orthologs | |||||||||
Summary |
[Homo sapiens] MFN1 deletion causes inability of the cell to undergo mitochondrial fusion, and therefore exhibit impaired induction of interferons and pro-inflammatory cytokines in response to viral infection - which results in increased viral replication.
[Mus musculus] Mfn1 deletion causes inability of the cell to undergo mitochondrial fusion, and therefore exhibit impaired induction of interferons and pro-inflammatory cytokines in response to viral infection - which results in increased viral replication.
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Entrez Gene | |||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171109:
The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||
Type | Protein coding | ||||||||
Genomic Location | Chromosome 1:88263740-88387147 | ||||||||
Strand | Reverse strand | ||||||||
Band | |||||||||
Transcripts |
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Interactions | |||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||
NETPATH | |||||||||
REACTOME |
Factors involved in megakaryocyte development and platelet production pathway
Hemostasis pathway
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KEGG | |||||||||
INOH | |||||||||
PID NCI | |||||||||
Cross-References | |||||||||
SwissProt | |||||||||
TrEMBL | F1MPL1 | ||||||||
UniProt Splice Variant | |||||||||
Entrez Gene | 515180 | ||||||||
UniGene | Bt.39430 | ||||||||
RefSeq | NM_001206508 | ||||||||
HUGO | |||||||||
OMIM | |||||||||
CCDS | |||||||||
HPRD | |||||||||
IMGT | |||||||||
EMBL | DAAA02001961 DAAA02001962 DAAA02001963 DAAA02001964 DAAA02001965 DAAA02001966 DAAA02001967 DAAA02001968 DAAA02001969 DAAA02001970 | ||||||||
GenPept | |||||||||
RNA Seq Atlas | 515180 | ||||||||