Version 5.4
Bos taurus Gene: KLHL12
Summary
InnateDB Gene IDBG-636078.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLHL12
Gene Name Kelch-like protein 12
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000009726
Encoded Proteins
IDBP-688010
kelch-like protein 12
IDBP-688016
kelch-like protein 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117153:
Gene Information
Type Protein coding
Genomic Location Chromosome 16:55494272-55516370
Strand Reverse strand
Band
Transcripts
ENSBTAT00000040284 ENSBTAP00000040061
ENSBTAT00000012826 ENSBTAP00000012826
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006513 protein monoubiquitination
GO:0006810 transport
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0016055 Wnt signaling pathway
GO:0016192 vesicle-mediated transport
GO:0016567 protein ubiquitination
GO:0048208 COPII vesicle coating
Cellular Component
GO:0000139 Golgi membrane
GO:0030134 ER to Golgi transport vesicle
GO:0031410 cytoplasmic vesicle
GO:0031463 Cul3-RING ubiquitin ligase complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000117153
View Gene Order
ENSMUSG00000026455
View Gene Order
Pathways
NETPATH
REACTOME
REACT_212636
Signaling by Wnt pathway
REACT_242703
Signaling by WNT in cancer pathway
REACT_217918
TCF dependent signaling in response to WNT pathway
REACT_234280
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_242720
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_214353
Signal Transduction pathway
REACT_236591
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_215163
degradation of DVL pathway
REACT_207087
Disease pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_200841
degradation of DVL pathway
REACT_111102
Signal Transduction pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
REACT_189085
Disease pathway
REACT_214014
Signaling by Wnt pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_227429
degradation of DVL pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_188257
Signal Transduction pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
INOH
PID NCI
wnt_canonical_pathway
Canonical Wnt signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca