InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: EDN1

Summary

InnateDB Gene

IDBG-636110.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EDN1

Gene Name

Endothelin-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008096

Encoded Proteins

IDBP-688008

Endothelin-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21730058

[Homo sapiens] EDN1 links TLR7 inflammatory signalling to cardiac fibrosis in autoimmune associated congenital heart block.

PMID 21730058

[Mus musculus] Edn1 links Tlr7 inflammatory signalling to cardiac fibrosis in autoimmune associated congenital heart block. (Demonstrated in human)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078401:
The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:44010444-44017425

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000010649

ENSBTAP00000010649

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0031707	endothelin A receptor binding
GO:0031708	endothelin B receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0001516	prostaglandin biosynthetic process
GO:0001569	patterning of blood vessels
GO:0001666	response to hypoxia
GO:0001701	in utero embryonic development
GO:0003100	regulation of systemic arterial blood pressure by endothelin
GO:0006885	regulation of pH
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007507	heart development
GO:0007585	respiratory gaseous exchange
GO:0007589	body fluid secretion
GO:0008217	regulation of blood pressure
GO:0008284	positive regulation of cell proliferation
GO:0009953	dorsal/ventral pattern formation
GO:0010460	positive regulation of heart rate
GO:0010613	positive regulation of cardiac muscle hypertrophy
GO:0010870	positive regulation of receptor biosynthetic process
GO:0014032	neural crest cell development
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0014826	vein smooth muscle contraction
GO:0015758	glucose transport
GO:0019229	regulation of vasoconstriction
GO:0019722	calcium-mediated signaling
GO:0030072	peptide hormone secretion
GO:0030185	nitric oxide transport
GO:0030335	positive regulation of cell migration
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0031583	phospholipase D-activating G-protein coupled receptor signaling pathway
GO:0032269	negative regulation of cellular protein metabolic process
GO:0035810	positive regulation of urine volume
GO:0035815	positive regulation of renal sodium excretion
GO:0042310	vasoconstriction
GO:0042313	protein kinase C deactivation
GO:0042474	middle ear morphogenesis
GO:0043179	rhythmic excitation
GO:0043406	positive regulation of MAP kinase activity
GO:0043507	positive regulation of JUN kinase activity
GO:0045793	positive regulation of cell size
GO:0045840	positive regulation of mitosis
GO:0046887	positive regulation of hormone secretion
GO:0048016	inositol phosphate-mediated signaling
GO:0048514	blood vessel morphogenesis
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050880	regulation of blood vessel size
GO:0051216	cartilage development
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process
GO:0060298	positive regulation of sarcomere organization
GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity