Bos taurus Gene: CREBBP | |||||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-636113.3 | ||||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||
Gene Symbol | CREBBP | ||||||||||||||||||||||||||||||||||||
Gene Name | CREB-binding protein | ||||||||||||||||||||||||||||||||||||
Synonyms | hmm291030 | ||||||||||||||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000026403 | ||||||||||||||||||||||||||||||||||||
Encoded Proteins |
CREB-binding protein
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Protein Structure | |||||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005339:
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009] |
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Gene Information | |||||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 25:3050214-3169185 | ||||||||||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||
Band | |||||||||||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 306 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||
NETPATH |
AndrogenReceptor pathway
TGF_beta_Receptor pathway
TNFalpha pathway
Hedgehog pathway
TCR pathway
IL4 pathway
IL6 pathway
Prolactin pathway
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REACTOME |
TRAF6 mediated IRF7 activation pathway
TRAF3-dependent IRF activation pathway pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Factors involved in megakaryocyte development and platelet production pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Pre-NOTCH Transcription and Translation pathway
PPARA activates gene expression pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Activation of gene expression by SREBF (SREBP) pathway
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
RORA activates circadian gene expression pathway
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REV-ERBA represses gene expression pathway
Circadian Clock pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
Notch-HLH transcription pathway pathway
Generic Transcription Pathway pathway
Transcriptional regulation of white adipocyte differentiation pathway
Regulation of gene expression by Hypoxia-inducible Factor pathway
HATs acetylate histones pathway
Cellular responses to stress pathway
Transmembrane transport of small molecules pathway
Organelle biogenesis and maintenance pathway
Developmental Biology pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Metabolism of lipids and lipoproteins pathway
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Pre-NOTCH Expression and Processing pathway
Signaling by Wnt pathway
Signaling by NOTCH1 in Cancer pathway
Mitochondrial biogenesis pathway
Innate Immune System pathway
Attenuation phase pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signal Transduction pathway
Orphan transporters pathway
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
Immune System pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Cellular response to hypoxia pathway
HSF1-dependent transactivation pathway
TCF dependent signaling in response to WNT pathway
Transcriptional activation of mitochondrial biogenesis pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Chromatin organization pathway
Signaling by NOTCH pathway
Cellular response to heat stress pathway
Chromatin modifying enzymes pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
formation of the beta-catenin:TCF transactivating complex pathway
Metabolism pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Cytosolic sensors of pathogen-associated DNA pathway
Gene Expression pathway
Disease pathway
Hemostasis pathway
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KEGG |
Wnt signaling pathway pathway
TGF-beta signaling pathway pathway
Cell cycle pathway
Renal cell carcinoma pathway
Notch signaling pathway pathway
Adherens junction pathway
Long-term potentiation pathway
Prostate cancer pathway
Jak-STAT signaling pathway pathway
Melanogenesis pathway
Huntington's disease pathway
Pathways in cancer pathway
Renal cell carcinoma pathway
TGF-beta signaling pathway pathway
Jak-STAT signaling pathway pathway
Notch signaling pathway pathway
Melanogenesis pathway
Wnt signaling pathway pathway
Cell cycle pathway
Long-term potentiation pathway
Adherens junction pathway
Prostate cancer pathway
Huntington's disease pathway
Pathways in cancer pathway
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INOH |
Wnt signaling pathway pathway
LIF signaling pathway
Notch signaling pathway pathway
TGF-beta signaling pathway
BMP2 signaling pathway
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PID NCI |
Presenilin action in Notch and Wnt signaling
IL12 signaling mediated by STAT4
Notch-mediated HES/HEY network
C-MYB transcription factor network
Signaling events mediated by Stem cell factor receptor (c-Kit)
Signaling events mediated by TCPTP
Hedgehog signaling events mediated by Gli proteins
Posttranslational regulation of adherens junction stability and dissassembly
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Cross-References | |||||||||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||||||||
TrEMBL | F1MD32 | ||||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||
Entrez Gene | 505453 | ||||||||||||||||||||||||||||||||||||
UniGene | Bt.9058 | ||||||||||||||||||||||||||||||||||||
RefSeq | NM_001164022 | ||||||||||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||||
EMBL | DAAA02057328 GJ062847 | ||||||||||||||||||||||||||||||||||||
GenPept | DAA15549 | ||||||||||||||||||||||||||||||||||||
RNA Seq Atlas | 505453 | ||||||||||||||||||||||||||||||||||||